Characterization of Spleen Transcriptome and Immunity Against Avian Colibacillosis After Immunization With Recombinant Attenuated Salmonella Vaccine Strains
نویسندگان
چکیده
منابع مشابه
Analysis of Spleen-Induced Fimbria Production in Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Strains
Salmonella enterica serovar Typhimurium genome encodes 13 fimbrial operons. Most of the fimbriae encoded by these operons are not produced under laboratory conditions but are likely to be synthesized in vivo We used an in vivo expression technology (IVET) strategy to identify four fimbrial operons, agf, saf, sti, and stc that are expressed in the spleen. When any three of these operons were del...
متن کاملEvaluation of Recombinant Attenuated Salmonella Vaccine Strains for Broad Protection against Extraintestinal Pathogenic Escherichia coli
Antibiotic-resistant bacterial infections are difficult to treat, producing a burden on healthcare and the economy. Extraintestinal pathogenic Escherichia coli (ExPEC) strains frequently carry antibiotic resistance genes, cause infections outside of the intestine, and are causative agents of hospital-acquired infections. Developing a prevention strategy against this pathogen is challenging due ...
متن کاملLive recombinant Salmonella oral vaccine against avian influenza viruses.
In 1997, the avian influenza virus (AIV) subtype H5N1 was first reported to infect humans.1 Up to 3 March 2015, the cumulative number of confirmed human cases of H5N1 was 784, with 429 deaths. There is no evidence that H5N1 viruses can transmit efficiently from person to person.2 Therefore, the key to prevention of a human H5N1 pandemic is to first control the H5N1 virus in birds. Traditionally...
متن کاملSalmonella flagellin is not a dominant protective antigen in oral immunization with attenuated live vaccine strains.
We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization with attenuated live vaccine strains.
متن کاملRapid, sensitive recovery of recombinant attenuated Salmonella enterica serovar Typhi vaccine strains from human blood.
Prior to initiating a phase 1 dose escalation trial of the safety and immunogenicity of live, oral, recombinant, attenuated Salmonella enterica serovar Typhi vaccine strains in human subjects, the suitability of conventional blood culture procedures to rapidly and reliably detect the organisms in human blood was investigated. Blood culture specimens, with and without added growth supplements, w...
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ژورنال
عنوان ژورنال: Frontiers in Veterinary Science
سال: 2018
ISSN: 2297-1769
DOI: 10.3389/fvets.2018.00198